Pakistan infant becomes youngest bone marrow donor in India


Eight-month-old Pakistani infant Rayan has become the youngest bone marrow donor in India by donating healthy bone marrow stem cells to his elder sister, who underwent successful transplant at a city hospital Bengaluru. The two-and-a-half-year-old Zeenia, hailing from Sahiwal in Pakistan, was suffering from Hemaphagocytic Lymphohistiocytosis (HLH), a rare disease in which bone marrow produces some abnormal cells which eat away the normal cells, resulting in high fever, low blood counts, liver and spleen enlargement, doctors said.

bone marrow donor
Bengaluru: Zeenia (L), two and half year old girl from Sahiwal in Pakistan who underwent successful Bone Marrow Transplant at Narayana Health City hospital in Bengaluru on Friday. Donor of bone marrow is her 8 months old brother Ryan (R) said to be the youngest donor with her father Zia Ulla (L). PTI Photo(PTI12_16_2016_000248B)

Calling it a potentially life threatening disorder, doctors said the only cure for this condition was bone marrow transplant. Zeenia was also diagnosed to have partial albinism since birth as well, they added. “After we diagnosed the girl was suffering from HLH, we discovered that her brother was Human leukocyte antigen (HLA) match for her,” said Dr Sunil Bhat, Senior Consultant and Head of Pediatric Hematology, Oncology and Bone Marrow Transplant at Narayana Health City hospital.

“As the donor is just eight months old to collect the adequate dosage, he was required to undergo the donation process twice at a gap of only few weeks,” Dr Bhat said. “By using small marrow extraction needles and with the assistance of a team of anesthetists and other members, we have successfully extracted enough marrow which helped cure Zeenia. Rayan has not only saved his sister, he also has the unique distinction of being the youngest marrow donor in India,” he added.

Doctors said the procedure was conducted in October and today Zeenia is cured of her “deadly disease” and ready to leave for Pakistan to lead a normal life. They have advised her parents about certain follow-ups that Zeenia needs to undergo after going back home. The doctors also said Rayan was doing “exceptionally” well and fine.

Zeenia had earlier undergone treatment at an armed forces hospital in Rawalpindi. Stating that there was “general fear factor” when they landed in India, Zeenia’s father Zia Ulla said his daughter was now fine and recovering. “From the time we landed following immigration I would say it was a very pleasant surprise … everyone was very fine and friendly,” he said.

Expressing similar sentiments, Zeenia’s mother Farzeen said it was very difficult for them to decide on bone marrow donation from her eight-month old son. “Obviously both children are important for us. When we got to know that they are match siblings and it was a promising option, we decided to take risk,” she said.

Dr. Sharat Damodar, Senior Consultant Hematologist and Clinical Director, Narayana Health City, said there was lot of misconception about bone marrow transplant like donor infecting diseases and others, “which is not true.” He said “if we compare India with United States which does about 10,000 transplants a year, our numbers are not even touching 2,000. For the size of India’s population which is four or five times the population of the US, the country should be doing five times that number.”

Dr. Bhat said Narayana Health sees about 40-odd patients from abroad getting transplants every year which amounts to 30 to 40 per cent.They come here because of non-availability of treatment in their respective countries, and cost worthiness compared to US and Europe, he said. Narayana Health’s bone marrow transplant division has completed 650 transplants till now. The division, which was doing on an average 60-70 transplants per year when started, is now doing about 150 per year.


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